A brand new 12 months, a brand new addition to the inventory portfolio – what could make extra sense than that? The fitting time to purchase, after all, is when shares are priced on the backside. Shopping for low and promoting excessive could also be a bit hackneyed, however it’s true, and fact has endurance.However the markets are up. The NASDAQ rose 43% in 2020, and the S&P 500 confirmed a acquire of 16%. With a market setting like that, discovering shares which can be caught within the doldrums is tougher than it seems to be. That is the place the Wall Road professionals can help.We used TipRanks’ database to pinpoint three shares that match a profile: a share value that has dropped over 30% within the final 12 months, however with not less than double-digit upside potential, in response to analysts. To not point out every has earned a Average or Sturdy Purchase consensus score.Esperion (ESPR)We’ll begin with Esperion, an organization that focuses on therapies for the therapy of elevated low-density lipoprotein levels of cholesterol – a significant component contributing to coronary heart illness. The corporate’s major product, bempedoic acid, is now accessible in pill type below the model names Nexletol and Nexlizet.In February 2020, each Nexletol and Nexlizet had been permitted as oral therapies to decrease LDL-C. Bempedoic acid stays in scientific trials of its efficacy in threat discount for heart problems. The trial, referred to as CLEAR Outcomes, is a large-scale, long-term examine, monitoring greater than 14,000 sufferers with top-line information anticipated within the second half of 2022. The examine covers 1,400 places in 32 international locations around the globe.Esperion shares peaked final February, after the FDA approvals, however since then, the inventory has declined. Shares are down 65% since their peak. Together with the drop in share worth, the corporate confirmed a fall in income from Q2 to Q3, with the highest line collapsing from $212 million to $3.eight million. Because the Q3 report, Esperion introduced pricing on a $250 million provide of senior subordinated notes, at 4%, due in 2025. The providing offers the corporate a lift in accessible capital for additional work on its improvement pipeline and its advertising efforts for bempedoic acid.Chad Messer, protecting ESPR for Needham, sees the word providing as a web constructive for Esperion. “We consider this money place might be ample to assist Esperion via 2021 and to profitability in 2022… We consider this financing ought to assist put to relaxation considerations concerning Esperion’s stability sheet. Regardless of a difficult launch for NEXLETOL and NEXLIZET, product progress has continued in 3Q in opposition to the backdrop of a contracting LDL-C market. This progress trajectory suggests potential for a speedy acceleration when circumstances enhance,” Messer wrote.To this finish, Messer charges ESPR shares a Sturdy Purchase, and his value goal, at $158, suggests the inventory has room for big progress this 12 months – as much as 481% from present ranges. (To look at Messer’s observe file, click on right here)Total, Esperion has 6 latest critiques on file, with a breakdown of 5 Buys and 1 Maintain to offer the inventory a Sturdy Purchase score from the analyst consensus. The shares, buying and selling at $27.16, have a median value goal of $63.33, implying a one-year upside of 133%. (See ESPR inventory evaluation on TipRanks)Intercept Pharma (ICPT)Liver illness is a critical well being menace, and Intercept Pharma is concentrated on creating therapies for a number of the extra harmful power liver circumstances, together with nonalcoholic steatohepatitis (NASH) and first biliary cholangitis (PBC). Intercept has a analysis pipeline based mostly on FXR, a regulator of bile acid pathways within the hepatic system.FXR’s motion impacts not simply the bile acid metabolism, but additionally the glucose and lipid metabolisms, and irritation and fibrosis across the liver. The lead compound, obeticholic acid (OCA), is an analog of the bile acid CDCA, and as such can take a job within the FXR pathways and receptors implicated in power liver illness. Treating liver illness via the FXR biology has direct purposes for PBC, and is displaying promise treating problems from NASH.ICPT shares dropped sharply final summer time, when the FDA rejected the corporate’s utility to approve OCA for therapy of NASH-related liver fibrosis. This delays the drug’s potential entry to a profitable market; there isn’t any present therapy for NASH, and the primary drug to win approval can have the lead in reaching a market estimated at $2 billion to $5 billion in potential annual gross sales. The impact on the inventory continues to be felt, and ICPT stays at its 52-week low level.In response, in December of 2020, Intercept introduced main adjustments in top-level administration, as CEO and President Mark Pruzanski introduced he is stepping down efficient January 1 of this 12 months. He’s succeeded by Jerome Durso, previously the corporate’s COO, who will even take a submit on the Board of Administrators. Pruzanski will stay as an advisor, and can maintain a director’s place on the corporate’s Board.Piper Sandler analyst Yasmeen Rahimi takes a deep dive into Intercept’s persevering with efforts to increase purposes of OCA and to resubmits its New Drug Utility to the FDA. She sees the management transition as a part of these efforts, and writes, “[We] consider that Dr. Pruzanski’s dedication to rework the liver house continues to be robust, and that he’ll proceed to information ICPT’s progress as an advisor and Board member. Moreover, we now have had the pleasure of working carefully with Jerry Durso and consider that he’ll rework the corporate and lead ICPT’s success in rising the PBC market and the trail to potential approval and industrial launch of OCA in NASH.”Rahimi takes a long-term bullish stance on ICPT, giving the inventory an Obese (i.e. Purchase) score and an $82 value goal. This determine signifies a formidable 220% upside for the subsequent 12 months. (To look at Rahimi’s observe file, click on right here)Wall Road is considerably extra divided on the drug maker. ICPT’s Average Purchase consensus score relies on 17 critiques, together with eight Buys and 9 Holds. Shares are priced at $25.82, and the typical value goal of $59.19 suggests an upside potential of 132% for the subsequent 12 months. (See ICPT inventory evaluation on TipRanks)Gilead Sciences (GILD)Gilead has had a 12 months like a firework – quick up and quick down. The beneficial properties got here in 1H20, when it appeared that the corporate’s antiviral drug remdesivir would grow to be a first-rate therapy for COVID-19. By November, nonetheless, despite the fact that remdesivir had been permitted, the World Well being Group (WHO) was recommending in opposition to its use, and the COVID vaccines now in the marketplace have made remdesivir irrelevant to the pandemic.This was solely one in every of Gilead’s latest headwinds. The corporate has been working, at the side of Galapagos (GLPG), on improvement of filgotinib as a therapy for rheumatoid arthritis. Whereas the drug acquired EU and Japanese approval in September 2020, the FDA has withheld approval and Gilead introduced in December that it was suspending US improvement efforts on the drug.Even so, Gilead retains a various and energetic analysis pipeline, with over 70 analysis candidates at various levels of the event and approval course of for a variety of illnesses and circumstances, together with HIV/AIDS, inflammatory & respiratory illnesses, heart problems, and hematology/oncology.On a constructive word, Gilead posted Q3 earnings above estimates, with the highest line income, of $6.58 billion, beating the forecast by 6% and rising 17% year-over-year. The corporate up to date its full-year 2020 steering on product gross sales from $23 billion to $23.5 billion.Among the many bulls is Oppenheimer analyst Hartaj Singh, who offers GILD shares an Outperform (i.e. Purchase) score and $100 value goal. Buyers stand to pocket a 69% acquire ought to the analyst’s thesis play out. (To look at Singh’s observe file, click on right here)Backing his stance, Singh writes, “We proceed to consider in our thesis of (1) a reliable remdesivir/different medicines enterprise in opposition to SARS-CoV flares, (2) a base enterprise (HIV/oncology/HCV) rising low-single digits over the subsequent couple of years, (3) working leverage offering larger earnings progress, and (4) a 3-4% dividend yield.” What does the remainder of the Road suppose? Wanting on the consensus breakdown, opinions from different analysts are extra unfold out. 10 Buys, 12 Holds and 1 Promote add as much as a Average Purchase consensus. As well as, the $73.94 common value goal signifies 25% upside potential from present ranges. (See GILD inventory evaluation on TipRanks)To seek out good concepts for beaten-down shares buying and selling at enticing valuations, go to TipRanks’ Finest Shares to Purchase, a newly launched instrument that unites all of TipRanks’ fairness insights.Disclaimer: The opinions expressed on this article are solely these of the featured analysts. The content material is meant for use for informational functions solely. It is rather necessary to do your individual evaluation earlier than making any funding.